GNAS and cancer: Among the intragenic chRNAs, we observed in all four libraries a non-colinear chRNA within GNAS, a gene coding for the G-protein alpha subunit, which is known to be associated with multiple human diseases including some cancers [31], and was recently found to be recurrently mutated in cystic pancreatic lesions related to invasive adenocarcinomas [32], as well as amplified in breast cancers [33].