In a study conducted in Japan, decreased ADAMTS-13 activity ( less than 5%) was found in 15.6% of patients with sepsis induced disseminated intravascular coagulation; whereas in USA a study showed that 31% of patients with severe sepsis had severe ADAMTS-13 deficiency [11,13]. The gene discussed is ADAMTS13; the disease is hyperinsulinemic hypoglycemia, familial, 4.