Thus, the pathological alteration in the brain caused by cerebral vasospasm-induced brain ischemia may result in the molecular alteration in the brain, which might include the up-regulation of NF-κB DNA-binding activity since abundant data suggest the activation of NF-κB induced by cerebral ischemia [30], [31], [32], [33]. Here, NFKB1 is linked to Cerebral ischemia.