VEGFA and malignant colon neoplasm: Examination of VEGFA expression in a panel of colon cancer cells indicated that cell lines with the wild type TGF-beta RII (CBS, GEO and FET [7]) expressed lower levels of VEGFA than those with mutant TGF-beta RII (RKO, C, HCT116 [7]) (Fig. 1A, left panel), suggesting an inverse relationship between TGF-beta signaling and VEGFA expression.