We show here that, in addition to inducing apoptosis, TGF-beta signaling can also inhibit expression of VEGFA and as a consequence, angiogenesis in colon cancer cells in vivo and that abrogation of TGF-beta enables increased VEGFA expression and angiogenesis, which could facilitate tumor growth and metastasis development. This evidence concerns the gene VEGFA and malignant colon neoplasm.