APP and early-onset autosomal dominant Alzheimer disease: For example, SNX9 participates in the formation of the narrow neck of endocytic vesicles before scission occurs [10], SNX13 controls trafficking of the G protein αs subunit [11], SNX3 is involved in neural development [12], and SNX17 is involved in trafficking of the amyloid precursor protein (APP) implicated in Alzheimer’s disease [13].