HDGF could stimulate the proliferation of fibroblast [7], vascular smooth muscle cells [8], endothelial cells [7] and a variety of cancer cell lines including hepatoma [9], melanoma [10], lung cancer [11] gastrointestinal stromal tumors [12], pancreatic cancer [13], and gastric carcinoma [14]. Here, HDGF is linked to hepatocellular carcinoma.