Indeed, WC in itself is considered to be a strong predictor of visceral fat.12] Mechanistically, increased secretion of free fatty acids and inflammatory cytokines combined with decreased secretion of adiponectin orchestrate in the multivariate culmination in visceral obesity and insulin resistance.37] At the level of the adipocyte, hyperinsulinaemia characteristic of IR activates 11-hydroxysteroid dehydrogenase in the omental adipose tissue and is followed by release of active cortisol. Here, ADIPOQ is linked to Insulin resistance.