PLCE1 and dengue disease: The effect size observed at PLCE1 rs3740360 was also similar to that observed in DSS patients.[6] It has been noted that hospitalised infants with dengue represent a group with the highest risk of death, and it is thought that this is partly related to an intrinsically more permeable vascular endothelium in this age group.[4] In infants with dengue, carriage of either risk alleles thus represent an additional risk variable alongside the presence of maternally-derived non-neutralising antibodies and poor compensatory reserve.[19]–[20]