In doing so, we expect to contribute to the wider understanding of the role of PLCE1 in health and disease, particularly in light of its association with nephrotic syndrome, regulation of blood pressure and esophageal cancer.[8], [9], [17] In light of the observed association with PLCE1 and nephrotic syndrome it is interesting that the degree of proteinuria has been proposed as a potential predictor in determining which dengue patients are at risk of developing more severe disease.[18]. This evidence concerns the gene PLCE1 and esophageal cancer.