The host factors that influence the clinical course of an individual infection include flavivirus infection history, host genotype, sex, age, and the presence of underlying medical conditions.[3]–[5] The first GWAS in dengue identified susceptibility loci for dengue shock syndrome (DSS) at MHC class I polypeptide-related sequence B (MICB) (C/T, rs3132468) on chromosome 6 and phospholipase C, epsilon 1 (PLCE1) (C/A, rs3740360) on chromosome 10.[6] The MICB gene encodes an activating ligand of natural killer (NK) cells (and possibly CD8+ T cells). This evidence concerns the gene PLCE1 and dengue disease.