Primary infection in the context of waning maternal antibody levels, immunological immaturity and vulnerable physiology make infants with dengue a distinct group.[19] Our data shows association between MICB rs3132468 and dengue in infants, with effect sizes in keeping with that observed in DSS patients.[6] We speculate that this reflects a prominent role for innate immunity and particularly NK cells in controlling early viral infection in infants; impaired control of viral replication could be a risk factor for clinically apparent dengue in this age group. This evidence concerns the gene MICB and viral infectious disease.