PLCE1 and dengue disease: The identification of variants of PLCE1 as being associated with severe dengue is intriguing.[6] Rare mutations of high penetrance within PLCE1 are associated with nephrotic syndrome, a condition characterised by oedema secondary to proteinuria and reduced vascular oncotic pressure.[8] Since plasma leak, proteinuria and hypovolemia are also characteristic features of severe dengue, it’s plausible that nephrotic syndrome and severe dengue share some common underlying pathophysiological processes.