Finally, amongst children and adults with DSS in these cohorts, we were able to confirm association of MICB rs3132468 and PLCE1 rs3740360 that was first observed in the previous GWAS.[6] Collectively, these findings provide further validation of the importance of MICB rs3132468 and PLCE1 rs3740360 risk genotypes to shaping the clinical phenotype of dengue and raises intriguing questions about their roles in disease pathogenesis. This evidence concerns the gene MICB and dengue disease.