In addition, pioglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) agonist inhibited vasopressin-induced chloride secretion through reducing CFTR mRNA levels in MDCK-C7 cell line [34] and suppressed cyst progression by decreasing apical CFTR expression in PCK rodent model of PKD [35]. The gene discussed is PPARG; the disease is cyst.