As a result, agents that downregulate such anti-apoptotic proteins as survivin, cellular FADD-like interleukin-1β-converting enzyme inhibitory protein (cFLIP), Bcl-2, and X-linked inhibitor of apoptosis protein (XIAP) can potentially sensitize cancer cells to the apoptotic effects of TRAIL [23], [24]. This evidence concerns the gene TNFSF10 and cancer.