SLIT3 and Hernia: Although Slit3-null mice have central diaphragmatic hernias–which are anatomically different than the retrosternal anterior hernias seen in Frem1crf11/eyes2 and Frem1eyes2/eyes2 mice–a similar pattern of decreased cell proliferation in the central tendon region of the diaphragm has been documented in both Slit3-null mice and Frem1eyes2/eyes2 mice [12], [29], [30].