Recessive mutations in FRAS1, FREM2, and GRIP1 cause Fraser syndrome which is characterized by cognitive impairments, cryptophthalmos, syndactyly, genital and renal anomalies and a range of other structural defects including CDH, lung lobulation defects and anal anomalies (OMIM #219000) [8], [13]–[18]. This evidence concerns the gene FREM2 and Fraser syndrome.