MYOC-associated POAG cases are usually characterized by markedly elevated IOP.[22] Mutations in OPTN have been associated with 1–2% of cases of normotensive glaucoma (NTG).[19], [23], [24] The extent to which WDR36, NTF4, ASB10 and TBK1 play a role in the high incidence of POAG is unclear.[14], [20], [21], [25]–[30] Loci and genes have also been reported for primary congenital glaucoma[31]–[36]. The gene discussed is OPTN; the disease is open-angle glaucoma.