Carriers of inherited mutations in BRCA1 and BRCA2 genes face a lifetime risk of ovarian cancer of 35–60% (average age of diagnosis 50 years) and 12–25% (average age of diagnosis 60 years) respectively, and also an elevated risk of fallopian tube and peritoneal carcinomas [1]–[3]. The gene discussed is BRCA1; the disease is ovarian cancer.