Finally, two pioneer studies using next-generation sequencing techniques [13], [31] reported an 18% prevalence in BRCA1 & BRCA2 (11.3% for BRCA1) mutations in ovarian cancer patients, while the Cancer Genome Atlas (TCGA) Research Network reported 14% (8.5% for BRCA1) [32]. The gene discussed is BRCA2; the disease is ovarian cancer.