ISG15 and malignant colon neoplasm: In colon cancer, better overall survival was predicted with higher levels of GFRA1 and THOC4, and lower levels of C7, GREM1, ISG15, LIFR, LOX, MMRN1, SCN4B, SPP1, TNC, TNFAIP6 and ZC3H8 (Figure 5A).