RANBP2 and Glucose intolerance: However, it is noteworthy that insufficiency of Ranbp2 is linked to glucose intolerance [35] and metabolic mitochondrial dysfunction [42], whereas kinesin-1 mediates glucose-dependent exocytosis of insulin-containing dense core secretory vesicles in pancreatic β-cells [58,90–92] and transport of glucose transport protein, GLUT4, in adipocytes [93].