In human HCC, most of the macrophages localized in the peritumoral stromal region mount an activated phenotype, with high expression of HLA-DR (Human Leukocyte Antigen), Interleukin 1 beta (IL-1β), Interleukin 6 (IL-6), and Interleukin 23 (IL-23), whereas they exhibit a HLA-DRlowIL-10low phenotype in the cancer nests [30, 32]. This evidence concerns the gene IL1B and hepatocellular carcinoma.