Comparing the gene expression profiles between T1 and T2 tumors and using partial least squares regression (PLS) analysis to adjust for lymph node status, differential grade, hormone receptor status, and breast cancer subtype, yielded 441 genes differentially expressed genes at FDR <1% (Supplementary Table  S1 available online at http://dx.doi.org/10.1155/2013/924971). Here, NR4A1 is linked to breast cancer.