FBXW7 and neoplasm: The same group used cationic liposomes for delivery of siRNA against the neoangiogenesis regulator, Argonaute 2 (Ago2) which resulted in Ago silencing in tumors together with apoptosis of tumor blood vessels and decreased tumor growth while no therapeutic effect was observed with cationic lipoplexes prepared with an irrelevant siRNA [188, 189].