It is noteworthy that, although the tumor accumulation of targeted and untargeted liposomes was similar, the MT1-MMP-targeted doxorubicin-loaded liposomes showed superior tumor protection thanks to enhanced uptake of the drug by tumor cells, in agreement with the results of Kirpotin et al. with anti-HER2 targeted liposomes [98]. This evidence concerns the gene ERBB2 and neoplasm.