The importance of toxicity in resistance to ABC by Doxil liposomes is supported by the suppression of IgM production after a second administration of oxaliplatin-loaded PEGylated liposomes compared to empty PEGylated liposomes [84] and by the evidence of ABC induction with PEGylated topotecan-loaded liposomes that have a fast drug release rate [85]. The gene discussed is CD40LG; the disease is aneurysmal bone cyst.