ERBB2 and cancer: Indeed, in a seminal study, Kirpotin et al. demonstrated that although HER2 antibody-targeted liposomes and untargeted liposomes had similar accumulation profiles in tumors after intravenous injection, they showed, by flow cytometry and histological analysis of disaggregated tumors, a 5.9-fold higher cancer cell accumulation of immunoliposomes versus untargeted liposomes [98].