In the same vein, the conjugation of IL-13 to PEGylated doxorubicin-loaded liposomes for astrocytoma targeting dramatically improved brain delivery of doxorubicin compared to untargeted liposomes and resulted in increased survival of intracranial U87 glioma-bearing mice after intraperitoneal administration [104]. This evidence concerns the gene IL13 and central nervous system cancer.