While inclusion of either Bcl-2 or MDR1 antisense oligonucleotides in cisplatin or doxorubicin-loaded targeted liposomes decreased primary tumor volume and intraperitoneal metastases load, further inhibition of tumor growth inhibition was obtained with targeted liposomes containing doxorubicin or cisplatin, Bcl-2 and MDR1 antisense oligonucleotides together with complete prevention of the development of detectable intraperitoneal metastases or ascites. The gene discussed is BCL2; the disease is neoplasm.