Roelofs et al. have shown the ability of N-BPs to inhibit the prenylation of Rap1A in a wide range of cultures of different types of primary cells and cell lines such as osteoclasts, osteoblasts, macrophages, epithelial, and endothelial cells, and breast, myeloma, and prostate tumor cells [16]. The gene discussed is RAP1A; the disease is plasma cell myeloma.