It was further suggested that monobenzyl ether hydroquinone induced the immunogenicity to melanocytes and melanoma cells by forming quinone-haptens to tyrosinase protein and by inducing the release of tyrosinase and melanoma antigen recognized by T cells-1 (MART-1) containing CD63+ exosomes following melanosome oxidative stress induction. The gene discussed is TYR; the disease is melanoma.