In contrast, antihypertensive agents that exert no or even beneficial metabolic effects, such as calcium channel blockers (considered neutral in this regard) and inhibitors of the renin-angiotensin-system (ACE inhibitors, angiotensin receptor blockers, and direct renin inhibitors), which have been shown to reduce new onset of diabetes [27], are considered preferred choices in this scenario. This evidence concerns the gene REN and diabetes mellitus.