Since the cytotoxic activity of LfcinB against cancer cells strongly depends on its structure, amphipathic nature and high net positive charge (+7, if compared to +4 for antimicrobial activity), this activity is, therefore, increased in LfcinB derivatives with clear cationic and hydrophobic moieties, while a glutamic acid-containing homologue of murine lactoferricin lacks the ability to kill cancer cells [48–50]. This evidence concerns the gene LTF and cancer.