The remaining 10% of ALS cases, known as familial ALS (FALS), are linked to mutations in specific genes [35] including SOD1, TDP-43, FUS, vesicle associated membrane protein-B (VAPB), optineurin, alsin, and ubiquilin-2 [18, 36–43]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.