A direct relation between the transcription factors and redox regulation in ALS is unknown; nevertheless dysregulation in the levels of NF-κB and HIF-1α has been observed in SALS patients, and activation of AP-1 in mutant SOD1 expressing cells, suggesting potential involvement of redox regulation in ALS pathology [78, 79]. The gene discussed is NFKB1; the disease is amyotrophic lateral sclerosis.