NUAK1 and neoplasm: Nevertheless, the role of kinases such as NUAK1 in T cells will be interesting to explore because it has been reported that tumour cells exposed to energy stress undergo a NUAK/ARK5-dependent cell cycle arrest resulting in the protection from apoptosis: in the absence of NUAK1/ARK5, energy stress results in cell death potentially due to the lack of the inhibition of energy consuming processes [20].