H19 and Silver-Russell syndrome: Recent studies have shown that epimutation (hypomethylation) of the paternally derived differentially methylated region (DMR) in the upstream of H19 (H19-DMR) on chromosome 11p15.5 and maternal uniparental disomy for chromosome 7 (upd(7)mat) account for ∼45% and 5−10% of SRS patients, respectively [1], [2].