ESR1 and acute lymphoblastic leukemia: Many groups have reported that the activation of PI3K/AKT/mTOR pathway is involved in various events, such as the critical crosstalk between PI3K/AKT signaling pathway and ROS that is essential for IL-7-mediated T-ALL cell survival, feedback activation from inhibition of other signals including MAPK pathway, HER2 and Estrogen receptor [45]–[48].