The tumor suppressor function of miR-34a is reflected in its epigenetic silencing during tumor progression [44], its positive regulation by p53 [24], and its ability to target and suppress expression of a number of oncogenes and other cancer relevant genes, including Axl, c-Met, CD44, MYCN, Notch1, Jagged 1, the Notch ligand Delta-like1, and the cell cycle regulators CCND1 and CDK6 [25], [45], [46], [47], [48], [49]. The gene discussed is NOTCH1; the disease is neoplasm.