Similarities between the current study and those previously published have been noted although the level of endemicity and epidemiology of HBV infection has varied with region: vaccine induced antibody decays with time, anti-HBc seroconversion occurs in those with low antibody concentrations, efficacy against chronic infection is maintained and the incidence of acute hepatitis and hepatocellular carcinoma drops dramatically [14], [32]. This evidence concerns the gene KRT88P and hepatocellular carcinoma.