The involvement of α2MG in aggressiveness of human cancer cells was hypothesized by in vitro studies [32]–[35], but the results of the present study represent the first in vivo evidence from a murine melanoma model confirmed in human patients, suggesting α2MG, Apo E and Apo A1 as novel potential serum predictors in cutaneous melanoma patients. The gene discussed is APOE; the disease is melanoma.