Recently, serum amyloid A was proposed as a prognostic marker in melanoma by MS-based proteomic profiling using hydrophobic C18 surfaced magnetic beads [26] and Bak was proposed as a candidate melanoma biomarker by using Hydrogel nanoparticles to analyze the low molecular weight serum proteins [27]; likely other recently developed techniques with promising potential may further improve the scenario[28]. Here, BAK1 is linked to melanoma.