A very recent paper has shown a dramatically reduction of β-klotho mRNA in adipose tissue in HIV-patients with and without lipodystrophy [33], supporting the hypothesis that the increase in muscle FGF-21 mRNA may in part be a compensatory mechanism to the reduced FGF-21 signalling in adipose tissue and that adipose tissue may be target tissue for FGF21 in HIV-patients. Here, FGF21 is linked to lipodystrophy.