Since published literature reported that Radix Ginseng, Rhizoma Coptidis, Cortex Phellodendri, three herbs used in FM, that have antioxidant effects [16, 21–23], we took the results into account and therefore hypothesized that FM may exert its hypoglycemic effect on type 2 diabetes primarily by improving sensitivity of peripheral tissues and hence decreasing insulin resistance and by the reducing oxidative stress. The gene discussed is INS; the disease is type 2 diabetes mellitus.