NFKB1 and Other metabolic disease: IKKβ activates nuclear factor-κB (NF-κB) which induces expression of NF-κB-dependent genes such as proinflammatory cytokines (e.g., TNFα and IL-1β), so that the suppression of this transcription factor could reduce metabolic disorders and the complications occurring in diabetes (retinopathy, nephropathy, and neuropathy) [8].