CXCL8 and gastric cancer: In gastric cancer patients, chronic Helicobacter pylori infection elevated IL-1β, IL-6, IL-8, TNF-α, and IFN-γ in the gastric mucosa, as well as activating the stem cell signaling network, consisting of the WNT, Notch, FGF, Hh, and BMP signaling pathways [29].