In Figure 2(a), the expressions of Shh preproproteins (Pre-Shh, 45 kDa), C-terminal (C-Shh, 25 kDa), and N-terminal (N-Shh, 20 kDa) peptides were all markedly increased in the BM cells of the AML patients. This evidence concerns the gene SHH and acute myeloid leukemia.