OLR1 and endothelial dysfunction: Furthermore, pretreatment with DPI or blockade of LOX-1 with anti-LOX-1 mAb or siRNA-LOX-1 prevented oxLDL-induced ROS generation and cell apoptosis, which suggests that the binding of oxLDL to LOX-1 and the consequent formation of ROS may be the first event in LOX-1-mediated endothelial dysfunction (Figures 1 and 4).