OLR1 and endothelial dysfunction: OxLDL is an important initiating factor for endothelial activation and injury contributing to endothelial dysfunction, one of the earliest hallmarks of atherosclerosis [8, 34, 35]; LOX-1, as the primary OxLDL receptor on endothelial cells, plays an important role in the pathogenesis of atherosclerosis [36–38].