In conclusion, our results provide evidence that the combined treatment with 5,7-dihydroxyflavone and TRAIL at subtoxic concentrations induced strong apoptotic response in human hepatocarcinoma HepG2 cells, acute leukemia Jurkat T cells, and cervical carcinoma HeLa cells, but did not affect the viability of normal hepatocytes. This evidence concerns the gene TNFSF10 and cervical carcinoma.