However, the precise molecular mechanism of quercetin action against fructose-induced hyperinsulinemia has not been elucidated, which prompted us to evaluate the effects of quercetin on pancreatic Akt/FoxO1 pathway impairment involved in β-cell mass and function using fructose-treated rats and INS-1 β-cells. This evidence concerns the gene FOXO1 and Hyperinsulinemia.