HGF could induce resistance to EGFR-TKIs via Met/PI3K/AKT activation, indicating that to overcome resistance to EGFR-TKIs induced by HGF-triggered activation of Met/PI3K/AKT pathway in mutant lung cancer, it was necessary to double blockade EGFR and HGF-Met signaling pathways. The gene discussed is PIK3CA; the disease is lung carcinoma.