Chondroitin sulfate proteoglycan 4 (CSPG4) is a unique glycoprotein-proteoglycan complex that has been implicated in numerous aspects of melanoma cell biology and carcinoma (including HNSCC) with usefulness as a CSC in glioblastoma [183–189]. The gene discussed is CSPG4; the disease is head and neck squamous cell carcinoma.