Similarly, Siu et al. demonstrated that Oct-3/4 along with TRA1-60, a tumour rejection antigen that is expressed on embryonic stem cells but vanishes upon differentiation, were detectable in the most invasive of six oral cancer cell lines suggesting that Oct-3/4 and TRA1-60 are markers indicating invasiveness [115]. The gene discussed is POU5F1; the disease is neoplasm.