Really, by means of sophisticated semeiotics images we cannot localize in mamma quadrant(s) the possible IRR of breast cancer, in BRCA 1, or BRCA1 mutation, E1373X in exon 12 and BRCA 2 in exons 9, 10, 11, 17, 18, and 23 positive women (and men) (Stagnaro-Neri and Stagnaro, 1995; Stagnaro, 2004, 2009; Stagnaro and Stagnaro-Neri, 2004a,b; Stagnaro, 2008; Stagnaro and Caramel, 2010; Caramel and Stagnaro, 2011). The gene discussed is BRCA1; the disease is breast carcinoma.