Mutations in tuberous sclerosis complex (TSC) 1/TSC2, neurofibromatosis 1 (NF1), and Phosphatase and tensin homolog (PTEN) lead to syndromic ASD with tuberous sclerosis, neurofibromatosis, or macrocephaly, respectively (Kelleher and Bear, 2008; Bourgeron, 2009; Hoeffer and Klann, 2010; Sawicka and Zukin, 2012). Here, PTEN is linked to Macrocephaly.