Western blotting detected γ-H2AX in 3 (37.5%) of 8 liver cirrhosis patients with no evident HCC occurrence, while 9 (75%) of 12 HCC cases showed a detectable protein band for γ-H2AX in the adjacent nontumorous liver tissues (Figure 3(a)). Here, H2AX is linked to hepatocellular carcinoma.