Immunohistochemical analysis showed that the LI of γ-H2AX in chronic hepatitis and liver cirrhosis was increased compared with normal livers (chronic hepatitis, 27.5 ± 15.8%, range from 5.0 to 59.3%, P < 0.005; liver cirrhosis, 56.2 ± 31.4%, range from 7.2 to 63.0%, P < 0.005, resp). This evidence concerns the gene H2AX and cirrhosis of liver.