H2AX and hepatocellular carcinoma: Immunohistochemical analysis showed that the mean LI of γ-H2AX in nontumorous liver tissues obtained from HCC patients with chronic hepatitis was relatively but not statistically increased as compared with that obtained from individuals with chronic hepatitis without HCC occurrence (35.7 ± 17.2%, range from 8.0 to 65.5%, P = 0.11).