H2AX and hepatocellular carcinoma: Intriguingly, dysplastic nodules showed a significantly increased γ-H2AX expression (74.1 ± 22.1%, range from 20.1 to 94.0%), which was significantly increased compared with those in liver cirrhosis (P < 0.005) and HCC (P < 0.005) (Figures 2(a) and 2(b)).