Bingham et al. (2002) subsequently studied the effect of insulin following suppression of basal insulin using somatostatin and found partial increase in glucose metabolism following insulin. Baker et al. (2011) found that in subjects with insulin resistance, there was regional reduction in glucose metabolism and more recently Hirvonen et al. (2011) showed reduced cerebral glucose metabolism in subjects with insulin resistance with improvement following insulin injection. This evidence concerns the gene INS and Insulin resistance.