IGF1 and ischemia: Specifically, the IEa and MGF/Ec/exon 4, 5, 6 transcripts are expressed in resting muscle, active muscle, damaged muscle, cardiac muscle especially post ischemia, exercised tendon, and brain again particularly in relation to ischemia; the expression in cardiac muscle and brain following ischemic insult suggests a role for MGF/Ec/exon 4, 5, 6 in the initiation of repair (reviewed in Dai et al., 2010).