Alternatively, in colorectal cancer, several investigators did not find any differences between patients with high or low TReg cell infiltration (Loddenkemper et al., 2006) whereas others have found an improved survival associated with a high density of local and systemic FoxP3+ cells suggesting no major immunosuppressive role of TReg cells in colorectal cancer (Salama et al., 2009). Here, FOXP3 is linked to colorectal cancer.