For example, transfection of tumor cells with IL-10 or systemic administration of exogenous IL-10 significantly suppressed tumor growth and led to tumor rejection in several different murine tumor models in vivo (Giovarelli et al., 1995; Berman et al., 1996; Fujii et al., 2001; Mumm et al., 2011). Here, IL10 is linked to neoplasm.