In more recent studies using both human and murine cells, generation of tumor-reactive cytotoxic CD4 Th1 cells were further shown to be induced, in part, by both the engagement of a specific co-stimulatory pathway of the tumor necrosis factor receptor (TNFR) family member, OX-40 (also known as CD134) and an intracellular mechanism relying on eomesodermin expression (Qui et al., 2011; Hirschhorn-Cymerman et al., 2012). The gene discussed is CD4; the disease is neoplasm.