IFNG and neoplasm: With respect to angiogenesis, IFN-γ is a potent inducer of several angiostatic chemokines, such as CXCL9 and CXCL10, from a variety of cells, including monocytes, macrophages, fibroblasts, endothelial cells, and tumor cells (Luster and Ravetch, 1987; Farber, 1990; Arenberg et al., 1996; Cole et al., 1998).