Of course, the different IFN-γ-inducible processes and effects, that are responsible for directly limiting tumor growth and progression, are not only dependent on tumor type, but also cytokine concentration and expression of the extracellular domains of the IFN-γ receptor subunits and their intracellular signaling transmission pathways among the various cells within a dynamic tumor environment (Ealick et al., 1991; Boehm et al., 1997). The gene discussed is IFNG; the disease is neoplasm.