IFNG and neoplasm: IFN-γ derived from Th1 cells can induce a cascade of events involving the priming and maturation of cytolytic CD8 T cells through activation of DCs at the sites of tumor growth and further induce tumor elimination through activation of NK cells and type 1 macrophages (Corthay et al., 2005; Quezada et al., 2010; Palucka and Banchereau, 2012).