In addition to enhancing and/or regulating T cell-mediated responses, that include both promoting long-term immunity and establishing or rebalancing immune cell homeostasis, CD4 T cells can also have a direct role in tumor elimination (Pardoll and Topalian, 1998; Quezada et al., 2010; Xie et al., 2010). This evidence concerns the gene CD4 and neoplasm.