NRTN and Parkinson disease: In animal models of PD, intrastriatal infusion of a recombinant AAV2-NRTN vector (CERE-120) was effective in behavioral tests, and NRTN immunoreactivity was traced to the striatum, GP, endopeduncular nucleus, SNpc, and SNpr (Kordower et al. 2006; Gasmi et al. 2007a,b; Herzog et al. 2007), suggesting both retrograde and anterograde transport.