As so few ATLD patients with any one MRE11 allele have been identified, it is difficult to definitively compare tumor predisposition, but as mitochondrial dysfunction and the response to ROS has been implicated as a major influence on the disease phenotypes, including neurodegeneration and tumorigenesis, it will be important to understand this aspect of ATM signaling and to what extent it is influenced or not by the Mre11 complex, ATMIN or other regulators or substrates of ATM. The gene discussed is ATM; the disease is neoplasm.