Mice expressing hypomorphic Mre11 complex alleles recapitulate most DDR related aspects of ATM deficiency but are not tumor prone and do not exhibit the same oxygen-dependent phenotypes observed in the absence of ATM (Williams et al., 2002; Theunissen et al., 2003; Ito et al., 2004; Difilippantonio et al., 2005; Stracker et al., 2007; Valentin-Vega et al., 2012). This evidence concerns the gene ATM and neoplasm.