EGF and neoplasm: BM-derived MSC have also been shown to migrate toward tumor hypoxia-induced secretion of growth factors (VEGF, PDGF, EGF) in pancreatic tumors, and contribute to neovascularization by homing to fast growing tumors and incorporating into blood vessels as atypical VEGF-secreting endothelial cells (Beckermann et al., 2008).