SHH and familial pancreatic carcinoma: Recently, Nakamura et al. (2010) identified that BM-derived pro-angiogenic cells are potential targets for Sonic Hedgehog (Shh), derived from the pancreatic tumors, and that Hh blockade can disrupt tumor angiogenesis in vivo, which is mediated through the impaired interaction BMDC with the neovasculature in pancreatic cancer (Nakamura et al., 2010).