BM-derived endothelial progenitor cells (EPC) stimulate neovascularization and pancreatic cancer growth, via the CXCL5/CXCL8/CXCR2 axis. CXCR2 in particular was required for BM-derived EPC mobilization during pancreatic tumor growth. Here, CXCR2 is linked to pancreatic neoplasm.