Such strategies may include reducing tumor neovascularization by targeting the ablation of BM derived EPC (Li et al., 2011); or genetic manipulation of (1) BMDC to block Hh signaling and regress the tumor vasculature (Nakamura et al., 2010), or (2) BM derived PSC by using the hGFAP promotor to develop targeted gene/drug therapy (Ding et al., 2009); or by unmasking the host's immune response by targeting BMD stromal fibroblasts that contribute to immunosuppression and tumor progression (Kraman et al., 2010). This evidence concerns the gene HGFAC and neoplasm.