Retrospective analyses of children and adults using the “low glucose suspend” feature of the Paradigm Veo, which automatically suspends insulin delivery for up to 2 hours after a hypoglycemic event occurs as determined by CGM, have shown both significant reductions in exposure to hypoglycemia and prevention of profound rebound hyperglycemia after the CGM system had automatically suspended insulin delivery for up to 2 hours [33,34]. The gene discussed is INS; the disease is Hyperglycemia.