Among different lymphoma models, nutlin has been shown effective in inducing wild type p53-dependent apoptosis of Hodgkin’s lymphoma (HL) [67,68], mantle cell lymphoma (MCL) [69-72], ALK-positive anaplastic large cell lymphoma (ALCL) [73], B-cell lymphoma (BCL) [74,75], Burkitt’s and follicular lymphoma [76-78], and adult T cell leukemia [79]. The gene discussed is ALK; the disease is mantle cell lymphoma.