REG1A and Sepsis: The main findings of this study, performed in patients at the time of admission to intensive or high dependency care, are: 1) that two recently described sepsis biomarkers (PSP and sCD25) perform at least comparably with PCT in identifying patients with sepsis; 2) PSP shares with PCT the property of reflecting sepsis severity; 3) HBP, despite promise in other settings, does not appear to perform well in this population; 4) a combinatorial approach to biomarker use might offer better discrimination in sepsis than use of a single biomarker alone.