Levels of PCT (3.1 (0.8 to 3.9) vs 0.2 (0.1 to 0.8) (P < 0.001)), sCD25, (4.5 (3.0 to 6.1) vs 1.5 (1.1 to 2.1) (P < 0.001)), PSP (116 (50 to 216) vs 16.5 (11.1 to 27.9) (P < 0.001)) and IL6 (373 (150 to 1435) vs 83.5 (31 to 261) (P < 0.001)) were higher in patients with sepsis than in patients with non-infective SIRS. Here, REG1A is linked to systemic inflammatory response syndrome.